Translational Animal Models in Drug Discovery and DevelopmenteBook - 2012
Animal models of diseases play a pivotal role in drug discovery and development, not only for proof of the concept studies of efficacy, PK/PD relationship but also for drug safety assessment. Since considerable differences in variables exist between animal models and human models (such as genetics, physiology, anatomy, gene expression, heterogeneity of disease conditions, etc.), not all the preclinical models are able to represent the pathophysiological conditions in human diseases. Therefore, partly due to the lack of congruency between animal and human disease models, several proposed therap.
Publisher: [Place of publication not identified] : Bentham Science Publishers, 2012
Characteristics: 1 online resource (viii, 275 pages)